Carlisle
Borough (town), seat (1751) of Cumberland county, southern Pennsylvania, U.S., in the Cumberland Valley, 18 miles (29 km) southwest of Harrisburg. James Le Tort, a French-Swiss Indian trader, settled with an Indian tribe near the site about 1720. The town, laid out in 1751, was named for Carlisle, Cumberland, England. It was the setting for continuous conflict with the Iroquois Confederacy until Benjamin
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